| Zach Line | RB | Yes | Out | Knee | Line is tending to a knee injury, and he will not be available for the NFC wild-card round versus the Vikings. |
| Michael Thomas | WR | Yes | Probable | Hand | Thomas is projected to take on the Vikings in the NFC wild-card round despite a hand injury. |
| Sheldon Rankins | DL | Yes | Out | Achilles | Rankins has been designated for the injured reserve list with a significant Achilles injury. |
| Marcus Davenport | DL | Yes | Out | Foot | Davenport has been added to the injured reserve list due to foot surgery. |
| Marcus Williams | DB | Yes | Probable | Groin | Williams is dealing with an injured groin, but it is anticipated that he will play in the NFC wild-card round against the Vikings. |
| Eli Apple | DB | Yes | Out | Ankle | Apple is on injured reserve with an ankle injury. |
| Vonn Bell | DB | Yes | Probable | Knee | Bell has a knee injury, but he is likely to take the field in the NFC wild-card round against the Vikings. |
| Dwayne Washington | RB | No | Probable | Knee | Washington hurt his knee, but he is expected to take on the Vikings in the NFC wild-card round. |
| Austin Carr | WR | No | Out | Ankle | Carr has landed on the injured reserve list due to ankle surgery. |
| Krishawn Hogan | WR | No | Out | Hamstring | Hogan has landed on the injured reserve list with a hamstring injury. |
| Keith Kirkwood | WR | No | Out | Hamstring | Kirkwood has landed on the Injured Reserve/Designated for Return list due to a hamstring injury. |
| Jason Vander Laan | TE | No | Out | Head | Vander Laan has landed on the injured reserve list with a head injury. |
| Garrett Griffin | TE | No | Out | Leg | Griffin has landed on injured reserve due to a left lower-leg injury. |
| Cameron Tom | OL | No | Out | Undisclosed | Tom has been designated for the injured reserve list with an undefined injury. |
| Johnson Bademosi | DB | No | Out | Foot | Bademosi has been placed on injured reserve due to a foot injury. |
| P.J. Williams | DB | No | Out | Undisclosed | |
| Saquan Hampton | DB | No | Out | Undisclosed | Hampton has hit the injured reserve list with an undefined ailment. |
