| Miles Sanders | RB | Yes | Probable | Ankle | Sanders is hampered by a low-grade lower ankle sprain, but he is expected to take part in the NFC wild-card round against the Seahawks. |
| Alshon Jeffery | WR | Yes | Out | Foot | Jeffery has hit the injured reserve list due to a Lisfranc injury in his left foot. |
| Nelson Agholor | WR | Yes | Out | Knee | Agholor has a knee injury, and he will not return for the NFC wild-card round against the Seahawks. |
| DeSean Jackson | WR | Yes | Out | Abdominal | Jackson has wound up on the injured reserve list due to core muscle surgery. It is unknown if he will be activated for the NFC divisional round should the team make it that far. |
| Zach Ertz | TE | Yes | Questionable | Ribs | Ertz is battling a fractured rib and a lacerated kidney. It is uncertain if he will face the Seahawks in the NFC wild-card round. |
| Lane Johnson | OL | Yes | Out | Ankle | Johnson is sidelined with a left high-ankle sprain, and he will not return to the field in time for the NFC wild-card round versus the Seahawks. |
| Fletcher Cox | DL | Yes | Questionable | Tricep | Cox is dealing with a triceps injury, and it is unknown if he will suit up against the Seahawks in the NFC wild-card round. |
| Derek Barnett | DL | Yes | Questionable | Ankle | Barnett has an ankle injury, and it has yet to be determined if he will play in the NFC wild-card round versus the Seahawks. |
| Jalen Mills | DB | Yes | Probable | Ankle | Mills is nursing a right ankle injury, but it is not expected to impede his status for the NFC wild-card round versus the Seahawks. |
| Darren Sproles | RB | No | Out | Hip Flexor | Sproles is on injured reserve due to a torn right hip flexor muscle. |
| Corey Clement | RB | No | Out | Shoulder | Clement has been placed on injured reserve due to a shoulder injury, and there is currently no timetable for return. |
| Brandon Brooks | OL | No | Out | Shoulder | Brooks is on injured reserve with a separated right shoulder. |
| Daeshon Hall | DL | No | Out | Knee | Hall has wound up on injured reserve with a torn ACL. |
| Malik Jackson | DL | No | Out | Foot | Jackson is on injured reserve with a Lisfranc injury to his foot. |
| Hassan Ridgeway | DL | No | Out | Ankle | Ridgeway is on injured reserve with an ankle injury, and a timetable for return has yet to be established. |
| Joe Ostman | LB | No | Out | Leg | Ostman has landed on injured reserve due to a torn ACL in his left knee. |
| Kamu Grugier-Hill | LB | No | Out | Back | Grugier-Hill is on injured reserve with a herniated disc in his back. |
| Avonte Maddox | DB | No | Probable | Abdominal | Maddox is battling an abdominal injury, but he is likely to be available for the NFC wild-card round against the Seahawks. |
| Ronald Darby | DB | No | Out | Hip Flexor | Darby has been placed on the injured reserve list with a hip flexor injury. |
| Rudy Ford | DB | No | Out | Abdominal | Ford is on injured reserve with an abdominal injury. |
| Sidney Jones | DB | No | Probable | Back | Jones is nursing a back injury, but he is expected to take on the Seahawks in the NFC wild-card round. |
