| Chris Carson | RB | Yes | Out | Hip | Carson has been sent to the injured reserve list due to a hip injury. |
| Josh Gordon | WR | Yes | Out | Suspension | Gordon will miss the remainder of the season as he has been suspended by the NFL for violating the league's policies on performance-enhancing substances and substances of abuse. |
| Will Dissly | TE | Yes | Out | Achilles | Dissly underwent surgery on his left Achilles and has been placed on injured reserve. |
| Mike Iupati | OL | Yes | Out | Neck | Iupati has a neck injury and is inactive against the Packers. |
| Duane Brown | OL | Yes | Probable | Knee | Brown had surgery to repair a knee injury and is active. |
| Joey Hunt | OL | Yes | Probable | Knee | Hunt is dealing with an injured fibula and will suit up against the Packers. |
| Jadeveon Clowney | DL | Yes | Probable | Abdominal | Clowney is battling a core muscle injury, but he is projected to take the field. |
| Quandre Diggs | DB | Yes | Probable | Ankle | Diggs has been sidelined with a high-ankle sprain, but it is unlikely to impede his status. |
| C.J. Prosise | RB | No | Out | Arm | Prosise has been designated for the injured reserve list due to an arm injury. |
| Rashaad Penny | RB | No | Out | Knee | Penny has been sent to the injured reserve list due to a torn ACL in his left knee. |
| Adam Choice | RB | No | Out | Lower Body | Choice has been added to injured reserve with a lower-body injury. |
| Jaron Brown | WR | No | Probable | Knee | Brown has an MCL sprain in his knee and is active. |
| Malik Turner | WR | No | Probable | Concussion | Turner is going through the league's concussion protocol and is active vs. the Packers. |
| Ed Dickson | TE | No | Out | Knee | Dickson is on the injured reserve list while he recuperates from offseason knee surgery. |
| Justin Johnson | TE | No | Out | Achilles | Johnson has reverted to the injured reserve list after clearing waivers with an Achilles injury. |
| Luke Willson | TE | No | Probable | Hip | Willson is nursing a hip injury. It is anticipated that he will line up against the Packers. |
| Phil Haynes | OL | No | Out | Hernia | Haynes has been activated from the PUP list, but it is unknown when he will make his season debut. |
| Ethan Pocic | OL | No | Out | Abdominal | Pocic has wound up on injured reserve with a core injury. |
| Justin Britt | OL | No | Out | Knee | Britt suffered a torn ACL and has been placed on the injured reserve list. |
| Al Woods | DL | No | Out | Suspension | Woods has been suspended four games by the NFL for violating the league's policies on performance-enhancing substances. He is eligible to return if the Seahawks make it deep into the playoffs. |
| Nazair Jones | DL | No | Out | Knee | Jones has been placed on injured reserve due to a knee injury. |
| Mychal Kendricks | LB | No | Out | Knee | Kendricks suffered a torn ACL in his knee, and he has been shut down for the remainder of the season. |
| Tedric Thompson | DB | No | Out | Shoulder | Thompson is on injured reserve due to a shoulder injury. |
| Neiko Thorpe | DB | No | Out | Hernia | Thorpe has landed on the injured reserve list after having surgery to repair a sports hernia. |
