| Deshaun Watson | QB | Yes | Probable | Back | Watson is bothered by a back injury, but it is active vs. the Chiefs. |
| Lamar Miller | RB | Yes | Out | Knee | Miller suffered a torn left ACL and MCL and has landed on the injured reserve list. |
| Kenny Stills | WR | Yes | Probable | Knee | Stills is tending to a knee injury, but is expected to play vs. the Chiefs. |
| DeAndre Hopkins | WR | Yes | Probable | Illness | Hopkins is active vs. the Chiefs. |
| Will Fuller | WR | Yes | Probable | Groin | Fuller is suffering from a groin injury and will play against the Chiefs. |
| Jordan Akins | TE | Yes | Out | Hamstring | Akins is managing a hamstring injury and is inactive vs. the Chiefs. |
| Laremy Tunsil | OL | Yes | Probable | Ankle | Tunsil is battling an ankle injury. He is likely to be active for the matchup vs. the Chiefs. |
| Tytus Howard | OL | Yes | Out | Knee | Howard has been placed on the injured reserve list due to a torn MCL. |
| J.J. Watt | DL | Yes | Probable | Pectoral | Watt has been activated from the Injured Reserve/Designated for Return list after recovering from surgery to repair a torn left pectoral muscle. It is expected that he will play vs. the Chiefs. |
| Benardrick McKinney | LB | Yes | Probable | Concussion | McKinney has a concussion, but is active vs. the Chiefs. |
| Bradley Roby | DB | Yes | Probable | Hamstring | Roby is hampered by a hamstring injury, but he is likely to be available against the Chiefs. |
| Tashaun Gipson | DB | Yes | Out | Back | Gipson Sr. has wound up on injured reserve due to a back injury. |
| Johnathan Joseph | DB | Yes | Questionable | Hamstring | Joseph is managing a hamstring injury, but is active vs. the Chiefs. |
| Joe Webb | QB | No | Out | Foot | Webb III will miss an extended period while on the injured reserve list due to a right foot injury. |
| Isaac Whitney | WR | No | Out | Wrist | Whitney has landed on the injured reserve list due to a wrist injury. |
| Jordan Thomas | TE | No | Probable | Illness | Thomas is ailing from an illness, but it is projected that he will play vs. the Chiefs. |
| Kahale Warring | TE | No | Out | Concussion | Warring has wound up on the injured reserve list with a concussion, and it is unclear when he will be activated. |
| Dylan Cole | LB | No | Out | Knee | Cole has been sent to the injured reserve list due to a torn ACL. |
| Jake Martin | LB | No | Probable | Knee | Martin is dealing with a knee injury, but it is anticipated that he will suit up against the Chiefs. |
| Jahleel Addae | DB | No | Out | Lower Body | Addae is hobbled by a lower-body injury and is inactive vs. the Chiefs. |
| Phillip Gaines | DB | No | Out | Ankle | Gaines is on injured reserve due to surgery to repair a severe high-ankle sprain. |
