| Dalvin Cook | RB | Yes | Probable | Shoulder | Cook is hampered by a left shoulder injury, but it is unlikely to impede his status for the NFC wild-card round against the Saints. |
| Eric Kendricks | LB | Yes | Questionable | Quadricep | Kendricks has a quadriceps injury, and it is unclear if he will be available against the Saints in the NFC wild-card round. |
| Ben Gedeon | LB | Yes | Out | Concussion | Gedeon has hit the injured reserve list with a concussion. |
| Alexander Mattison | RB | No | Probable | Ankle | Mattison is dealing with an ankle injury, but it is likely that he will play in the NFC wild-card round against the Saints. |
| Chad Beebe | WR | No | Out | Ankle | Beebe has been added to the injured reserve list after surgery to repair torn ligaments in his ankle. |
| Brett Jones | OL | No | Questionable | Knee | Jones is on the Injured Reserve/Designated for Return list with a knee injury. It remains to be seen if he will be activated in time for the NFC wild-card round against the Saints. |
| Ifeadi Odenigbo | DL | No | Questionable | Hamstring | Odenigbo is bothered by a hamstring injury, and it is up in the air if he will take on the Saints in the NFC wild-card round. |
| Armon Watts | DL | No | Out | Leg | Watts has been placed on injured reserve with a leg injury. |
| Stephen Weatherly | DL | No | Questionable | Illness | Weatherly is battling an illness, and it is undetermined if he can fight it off in time for the NFC wild-card round against the Saints. |
| Hercules Mata'afa | DL | No | Out | Spine | Mata'afa has been sidelined with a cervical spine injury, and there is currently no timetable for his return. |
| Mackensie Alexander | DB | No | Out | Knee | Alexander is nursing a knee injury, and he will not suit up against the Saints in the NFC wild-card round. |
| Andrew Sendejo | DB | No | Questionable | Illness | Sendejo is ailing from an illness, and it is uncertain if the symptoms will subside in time for the NFC wild-card round versus the Saints. |
| Mike Hughes | DB | No | Out | Neck | Hughes is on injured reserve with a neck injury. |
| Holton Hill | DB | No | Out | Undisclosed | |
